NOT KNOWN DETAILS ABOUT TRAMADOL (RETARD)

Opioid action is because of both equally minimal affinity binding from the father or mother compound and higher affinity binding from the O-demethylated metabolite M1 to μ-opioid receptors. In animal types, M1 is as many as 6 periods a lot more powerful than tramadol in manufacturing analgesia and two hundred times more potent in μ-opioid binding